Faculty & Staff

Loree Heller

Associate Professor

Office: MDT 1510

Phone: 813-974-4637

Email

 

 

Education

PhD, ßÙßÇÂþ»­ College of Medicine, Tampa, FL, Biochemistry and Molecular Biology
MS, Long Island University, Greenvale, NY, Medical Microbiology and Immunology
BS, Oregon State University, Corvallis, OR, Microbiology


Research

Nucleic acid electrotransfer, Non-viral gene therapies, Pattern recognition receptors


Memberships

American Society for Clinical Pathology
American Society of Gene and Cell Therapy
American Association of Immunologists
American Association for Cancer Research
National Academy of Inventors
International Society for Electroporation

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Research Grants

NIH NCI R01 “DNA-specific pattern recognition receptor activation following DNA electroporationâ€


Recent Publications

Conniff, Amanda & Cason, Aneeshea & Alvarado, Juliana & Bhandary, Manya & Patel, Shreena & Singh, Julie & Heller, Richard & Heller, Loree. (2024). Direct Plasmid DNA Transfection into Differentiated Mouse C2C12 Myotubes. Re:GEN Open. 4. 1-8. 10.1089/regen.2023.0026. 

Conniff, Amanda & Tur, Jared & Kohena, Kristopher & Zhang, Min & Gibbons, Justin & Heller, Loree. (2023). DNA Electrotransfer Regulates Molecular Functions in Skeletal Muscle. Bioelectricity. 10.1089/bioe.2022.0041.

Sales, Amanda & Tur, Jared & Kohena, Kristopher & Zhang, Min & Gibbons, Justin & Heller, Loree. (2022). Transcriptomic Analysis of the Acute Skeletal Muscle Effects after Intramuscular DNA Electroporation Reveals Inflammatory Signaling. Vaccines. 10. 2037. 10.3390/vaccines10122037. 

Bhandary, Manya & Sales, Amanda & Miranda, Kaitlyn & Heller, Loree. (2022). Acute Effects of Intratumor DNA Electrotransfer. Pharmaceutics. 14. 2097. 10.3390/pharmaceutics14102097. 

Sales, Amanda & Encalada, G & Patel, S & Bhandary, M & Al-Takrouri, F & Heller, Loree. (2022). Poly(I:C) transfection induces a pro-inflammatory cascade in murine mammary carcinoma and fibrosarcoma cells. RNA Biology. 19. 841-851. 10.1080/15476286.2022.2084861. 

Heller, Loree & Shi, Guilan & Synowiec, Jody & Heller, Richard. (2022). Abstract 3289: PD-1 peptide/IL-12 combination gene therapy for the treatment of melanoma. Cancer Research. 82. 3289-3289. 10.1158/1538-7445.AM2022-3289. 

BoÅ¡njak, MaÅ¡a & Znidar, K. & Sales, Amanda & Jesenko, Tanja & Markelc, B. & Semenova, Nina & Tur, J. & Kohena, K. & Kranjc, Simona & Heller, Loree & Cemazar, Maja. (2022). In vitro and in vivo correlation of skin and cellular responses to nucleic acid delivery. Biomedicine & Pharmacotherapy. 150. 113088. 10.1016/j.biopha.2022.113088. 

Heller, Loree & Znida, Katarina & BoÅ¡njak, MaÅ¡a & Sales, Amanda & Jesenko, Tanja & Markelc, Bostjan & Tur, Jared & Semenova, Nina & Cemazar, Maja. (2022). Comparison of DNA sensing by non-immune cells and tissues. The Journal of Immunology. 208. 164.06-164.06. 10.4049/jimmunol.208.Supp.164.06. 

Heller, Loree & Bulysheva, Anna & Arpag, S. & Sales, Amanda & Kohena, K. & Shi, G. & Semenova, Nina & Heller, Richard & Cemazar, Maja. (2021). Growth environment influences B16.F10 mouse melanoma cell response to gene electrotransfer. Bioelectrochemistry. 140. 107827. 10.1016/j.bioelechem.2021.107827. 

Dolezalova, Eva & Malik, Muhammad & Heller, Loree & Heller, Richard. (2021). Delivery and expression of plasmid DNA into cells by a novel non-thermal plasma source. Bioelectrochemistry. 140. 107816. 10.1016/j.bioelechem.2021.107816. 

Bulysheva, Anna & Heller, Loree & Francis, Michael & Varghese, Frency & Boye, Carly & Heller, Richard. (2021). Monopolar Gene Electrotransfer Enhances Plasmid DNA Delivery to Skin. Bioelectrochemistry. 140. 107814. 10.1016/j.bioelechem.2021.107814. 

Jesenko, Tanja & BoÅ¡njak, MaÅ¡a & Markelc, Bostjan & Sersa, Gregor & Znidar, Katarina & Heller, Loree & Cemazar, Maja. (2020). Radiation Induced Upregulation of DNA Sensing Pathways is Cell-Type Dependent and Can Mediate the Off-Target Effects. Cancers. 12. 10.3390/cancers12113365. 

Heller, Loree & Thinard, Reynald & Chevalier, Melanie & Arpag, Sezgi & Jing, Yu & Greferath, Ruth & Heller, Richard & Nicolau, Claude. (2020). Secretion of proteins and antibody fragments from transiently transfected endothelial progenitor cells. Journal of Cellular and Molecular Medicine. 24. 10.1111/jcmm.15511. 

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PATENTS

US 6,714,816 B1 (Issued March 30, 2004): Electroporation and electrophoresis system and method for achieving molecular penetration into cells in vivo. Inventors: Heller R, Gilbert R, Jaroszeski MJ, Heller LC, Lucas ML. Assignee: ßÙßÇÂþ»­.

US 7,668,592 B2 (Issued February 23, 2010): Electroporation and electrophoresis system and method for achieving molecular penetration into cells in vivo. Inventors: Heller R, Gilbert R, Jaroszeski MJ, Heller LC, Lucas ML. Assignee: ßÙßÇÂþ»­.

US 8,802,643 (Issued August 12, 2014) Method for the treatment of malignancies, Inventors: Heller, R., Heller, L.C. Assignee: ßÙßÇÂþ»­.

US 8,895,248 (Issued November 25, 2014) Method for Detecting Salmonella Species By Assaying Outer Membrane Porin F (ompF). Inventors: Tatavarthy, A., Cannons, A.C., and Heller, L.C. Assignee: ßÙßÇÂþ»­.

US 9,410,212 (Issued August 9, 2016) Kit for Detecting Salmonella Species By Assaying Outer Membrane Porin F (ompF). Inventors: Tatavarthy, A., Cannons, A.C., and Heller, L.C. Assignee: ßÙßÇÂþ»­. https://www.google.com.ar/patents/US9410212 

US 9,610,364 (Issued April 4, 2017) Method for the treatment of malignancies, Inventors: Heller, R., Lucas, M.L., Heller, L.C. Assignee: ßÙßÇÂþ»­.

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